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In patients with cirrhosis of the liver (rooms A and Modafinil according to the Child-Pugh prorate increase), the endorsement of sildenafil decreases, which leads to an increase in the AUC (84%) and C max (47%) values ??compared with those of the presence of normal liver assignment in patients of the yet age group. The pharmacokinetics of sildenafil in patients with grimly impaired liver behave (refinement C on the Child-Pugh scale) has not been studied.

treatment of erectile dysfunction, characterized by way of the inability to accomplish alias upkeep of an erection of the penis, enough during a adequate intercourse. Sildenafil is effective all over the presence of sexual stimulation. Contraindications.

having a bun in the oven liver omission (class C according to Child-Pugh classification); austere cardiovascular diseases (severe heart failing, capricious angina pectoris, suggestion, alias myocardial infarction, life-threatening arrhythmias, arterial hypertension (BP> 170/100 mm Hg) or hypotension (BP With caution: anatomical deformation penis (angulation, cavernous fibrosis, that is, Peyronie's powerlessness); diseases that predispose to the situation of priapism (sickle chamber anemia, multiple myeloma, leukemia, thrombocythemia); diseases accompanied next to bleeding; ulcerative proclivity of the stomach and duodenal mission in the juncture of the duodenum; ; merciless renal ruin (CC less than 30 ml / min); a case of evolvement of anterior non-arteritic ischemic neuropathy of the optic nerve in past; contemporary eating of alpha-blockers.

For most full-grown patients, the recommended serving is 50 mg after generally 1 hour of pre-sexual activity. Delightful into account the effectiveness and tolerability, the allocation may be increased to come 100 mg, or reduced more willingly than Provigil 25 mg.